منابع مشابه
Cultures of cerebellar granule neurons.
INTRODUCTIONPrimary cultures of granule neurons from the post-natal rat cerebellum provide an excellent model system for molecular and cell biological studies of neuronal development and function. The cerebellar cortex, with its highly organized structure and few neuronal subtypes, offers a well-characterized neural circuitry. Many fundamental insights into the processes of neuronal apoptosis, ...
متن کاملElectrophoretic behavior of cerebellar granule neurons.
The electrophoresis of cerebellar granule neurons is observed, and a theoretical model proposed to simulate its electrophoretic behavior. We assume that the surface of a neuronal cell carries dissociable acidic functional groups, and the liquid phase contains a mixed (a:b) + (c:b) electrolyte, where a and c are the valences of cations and b is the valence of anions. The cations of valence c are...
متن کاملSilent synapses in developing cerebellar granule neurons.
Silent synapses are excitatory synapses endowed exclusively with N-methyl-D-aspartate (NMDA) responses that have been proposed to acquire alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) responses during development and after long-term potentiation (LTP). These synapses are functionally silent because of the Mg(2+) block of NMDA receptors at resting potentials. Here we provide ev...
متن کاملBrevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neurons.
Brevetoxins (designated PbTx-1 to -10) are potent lipid-soluble polyether compounds that are known to bind to and modulate voltage-gated sodium channel activity. To investigate whether brevetoxins produce direct central nervous system neurotoxic effects, cultured rat cerebellar granule neurons were exposed to brevetoxins in Locke's buffer for 2 h at 22 degrees C. Neuronal injury was quantified ...
متن کاملThe Time Course of JNK and P38 Activation in Cerebellar Granule Neurons following Glucose Deprivation and BDNF Treatment
Low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (MAPK) signaling pathways. It has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (CGNs). In this study, we have examined the activation of JNK, p38kinase and ERK1/2 pathways in low glucose medium in CGNs. The CGNs were prepared ...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Protocols
سال: 2008
ISSN: 1559-6095
DOI: 10.1101/pdb.prot5107